GENERIC NAME: Acyclovir.
Each 8 ml bottle contains:
Aciclovir 8 mg.
The chemical name is 2-amino-9-(2-hydroxyethoxymethyl)-1H-purin-6-one.
Molecular formula: C8H11N5O3
Molecular Weight: 225.21
A colorless clear liquid.
PHARMACOLOGY AND TOXICOLOGY:
Acyclovir (AZV) is effective against type I and II Herpes Simplex Virus (HSV)，it is also effective against Varicella-Zoster Virus (VZV), but it is weaker on EB (Epstein-Barr) Virus and Cytomegalovirus. Acyclovir effect on Herpes Simplex Virus type I,II and Varicella-Zoster Virus is due to the phosphorylation of AZV by the thymidine kinase (TK) encoded by the virus to acyclovir monophosphate, the latter is further catalyzed by cellular enzymes to form Acyclovir diphosphate, Acyclovir triphosphate. Acyclovir triphosphate is a strong inhibitor of herpes simplex virus DNA polymerase, which binds to the enzyme as a substrate for viral DNA polymerase and is incorporated into viral DNA, thereby terminating the synthesis of viral DNA.
Aciclovir is absorbed through the corneal epithelium and superficial ocular tissues, and achieves significant concentrations in aqueous humour. Small quantities (2-16% of the applied dose) appear in the urine. In animal studies low levels of aciclovir could be detected in blood after topical application to the eye.
It is Antiviral drugs for treatment of Herpes Simplex Keratitis (eye infections caused by the herpes simplex virus).
DOSAGE AND ADMINISTRATION:
The recommended dosing regimen is to apply prescribed drops of Aciclovir eyedrop in the lower corner of eye of the affected eye 5 times per day (approximately every 2 hours while awake) until the corneal ulcer heals.
Safety and efficacy of Acyclovir ophthalmic ointment in pediatric patients below the age of two years has not been established.
Overdose of topical application of acyclovir is unlikely because of minimal absorption.
The most common adverse reactions (2-10%) reported in patients were eye pain (stinging), punctuate keratitis and follicular conjunctivitis. Rare reports of blepharitis and very rare reports of immediate hypersensitivity reactions including angioedema and urticaria have been observed post-marketing in patients taking AVACLYR.
Aciclovir is contraindicated for patients who develop sensitivity to Acyclovir.
Advise patients to wash hands well and pull down lower lid of the affected eye to create a cavity at the corner of eye. After application of eye drop patient is advised to keep close the eye.
PREGNANCY AND LACTATION:
Data for any specific impact on Eye during pregnancy is not available.
Acyclovir concentrations have been documented in breast milk following oral administration of acyclovir. There is no information regarding the presence of acyclovir in human milk following ocular administration, the effects on the breastfed infant, or the effects on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for acyclovir, and any potential adverse effects on the breast-fed child from acyclovir or from the underlying maternal condition.
Do not use medications containing valacyclovir while using acyclovir.
STORAGE: Protect from light and store in a cool, dry place below 25℃
PACKING: 8 ml bottle in a box
SHELF LIFE: 3 Years.
KEEP OUT OF REACH OF CHILDREN